Diagnostic accuracy of microalbuminuria in secondary nephropathies
DOI:
https://doi.org/10.2478/AMB-2024-0049Keywords:
diagnostic accuracy, ROC, urinary microalbumin to creatinine ratio, diabetic nephropathy, hypertensive nephropathy, pre-eclampsiaAbstract
Introduction: Microalbuminuria is an initial indicator of kidney damage in diabetic nephropathy (DN), hypertensive nephropathy (HN), and pre-eclampsia (PE). This study aims to assess the diagnostic accuracy of urinary microalbumin to creatinine ratio
(UM/CR) as an early diagnostic tool in patients with DN, HN, and PE. Materials and methods: In this cross-sectional study, we included a total of 143 subjects divided into three groups: first-group patients with DN (n = 30), second-group patients with HN (n = 23), and
third-group women with PE (n = 30). Additionally, we included a control group comprising 60 healthy subjects. The study employed fresh urine samples to measure UM/CR by the turbidimetric method and creatinine by the Jaffe reaction. We also estimated the UM/CR and glomerular filtration rate. Some biochemical parameters were measured in blood sera. Results: We determined the cut-off value of UM/CR to be 30.0 mg/g. For patients with DN, UM/CR had a sensitivity of 41.5%, a specificity of 90%, and an overall diagnostic accuracy of 53.1% for detecting DN. Similarly, for patients with HN, UM/CR had a sensitivity of 44.8% and a specificity of 86.1%, with an overall diagnostic accuracy of 57.8% for detecting HN. In contrast, for women with PE, UM/CR had a sensitivity of 100%, a specificity of 93.3%, and a diagnostic accuracy of 96.7% for predicting PE. Conclusion: UM/CR can be used as a good screening tool for early detection of PE, while it has low sensitivity as an early marker for patients with DN and HN.
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Copyright (c) 2024 I. Kostovska, K. Trajkovska, D. Labudovic, S. Cekovska, O. Kostovski, G. Spasovski (Author)
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