Role of Helicobacter pylori eradication therapy in the management of recurrent aphthous stomatitis: a case report
DOI:
https://doi.org/10.2478/AMB-2024-0064Keywords:
Helicobacter pylori, recurrent aphthous stomatitis, eradication therapy, laser therapyAbstract
Recurrent aphthous stomatitis (RAS) is one of the most frequently encountered oral mucosal lesions. The RAS is characterized by recurrent painful ulcers, which can be either single or multiple. The prevalence rate of RAS ranges from 5 to 60% among the different ethnic and socio-economic groups. To date, RAS is one of the least understood oral diseases. It causes many problems for the affected individual due to the diverse precipitating factors and recurrent nature. Prompt diagnosis and management of RAS is a challenge
for clinicians. Several factors, such as nutritional deficiencies, genetic, immunological, haematological, hormonal, trauma, and stress, were identified as causal and precipitating factors. Various micro-organisms, including Helicobacter pylori (H. pylori), are believed to
be associated with the development of RAS. H. pylori is a microaerophilic, gram-negative bacterium that colonises the gastric mucosa. Very few reports are available in the literature highlighting the association between H. pylori and RAS. Pain relief, fast ulcer healing increased ulcer-free period are the treatment strategies used for RAS. Identifying the causal factors helps the better management of the patients. The present case highlights the difficulties faced by a geriatric patient due to recurrent major aphthous ulcers and the
successful management of the recurrent ulcers followed by H. pylori eradication therapy.
References
Scully C, Shotts R. ABC of oral health: Mouth ulcers and other causes of orofacial soreness and pain. BMJ 2000; 321(7254):162.
Gill Y, Scully C. Mouth ulcers: a study of where members of the general public might seek advice. Br Dent J. 2007; 202(6):E16–E16.
Daley TD, Armstrong JE. Oral manifestations of gastrointestinal diseases. Can J Gastroenterol. 2007; 21(4):241-4.
Chiang CP, Yu-Fong Chang J, et al. Recurrent aphthous stomatitis – Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formos Med Assoc. 2019; 118(9):1279–89.
Queiroz SIML, Silva MVA da, Medeiros AMC de, et al. Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis. An Bras Dermatol. 2018; 93(3):341–6.
Gomes CC, Gomez RS, Zina LG, Amaral FR. Recurrent aphthous stomatitis and Helicobacter pylori. Med Oral Patol Oral Cir Bucal. 2016; 21(2):e187–91.
Ślebioda Z, Szponar E, Kowalska A. Recurrent aphthous stomatitis: genetic aspects of etiology. Advances in Dermatology and
Allergology/Postȩpy Dermatologii I Alergologii. 2013; 30(2):96.
Bankvall M, Sjöberg F, Gale G, et al. The oral microbiota of patients with recurrent aphthous stomatitis. J Oral Microbiol. 2014; 6:25739.
Diaz A, Pereira-Lopes O, Barbosa E, et al. Behavior of the recurrent aphthous stomatitis as a dental urgency at Vedado’s University Polyclinic. Rev Port Estomatol Med Dent Cir Maxilofac. 2015; 56(3):144–8.
Kim YJ, Choi YS, Baek KJ, et al. Mucosal and salivary microbiota associated with recurrent aphthous stomatitis. BMC Microbiol. 2016; 16 Suppl 1:57.
Adler I, Muiño A, Aguas S, et al. Helicobacter pylori and oral pathology: relationship with the gastric infection. World J Gastroenterol. 2014; 20(29):9922–35.
Gülseren D, Karaduman A, Kutsal D, Nohutcu RM. The relationship between recurrent aphthous stomatitis, and periodontal disease and Helicobacter Pylori infection. Clin Oral Investig. 2016; 20(8):2055–60.
Li L, Gu H, Zhang G. Association between recurrent aphthous stomatitis and Helicobacter pylori infection: a meta-analysis. Clin Oral Investig. 2014; 18(6):1553-60.
Afghari P, Khazaei S, Kazemi S, et al. The role of Helicobacter pylori in the development of recurrent aphthous stomatitis: SEPAHAN systematic review no. 9. Dent Res J [Isfahan]. 2011; (Suppl 1):S2-8.
Dowsett SA, Kowolik MJ. Oral Helicobacter pylori: can we stomach it? Crit Rev Oral Biol Med. 2003; 14(3):226-33.
Maleki Z, Sayyari AA, Alavi K, et al. A study of the relationship between Helicobacter pylori and recurrent aphthous stomatitis using a urea breath test. J Contemp Dent Pract. 2009; 10(1):9-16.
Rao LN, Ramanna VK, Avalahalli MG. The effect of gastric helicobacter pylori eradication on the clinical course of recurrent aphthous stomatitis – a systematic review. J. Evolution Med. Dent. Sci. 2019; 8(47):3554-3559.
Karaca S, Seyhan M, Senol M, et al. The effect of gastric Helicobacter pylori eradication on recurrent aphthous stomatitis. Int J Dermatol. 2008;47(6):615-7.
Gao Y, Gupta N, Abdalla M. Recurrent Aphthous Stomatitis Improved after Eradication Therapy for Helicobacter pylori. Case Rep Gastrointest Med. 2021; 5543838.
Taş DA, Yakar T, Sakalli H, Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. J Oral Pathol Med. 2013; 42(1):89-94.
Vale FA, Moreira MS, de Almeida FC, Ramalho KM. Low-level laser therapy in the treatment of recurrent aphthous ulcers: a systematic review. Scientific World Journal. 2015;150412.
Stehlikova Z, Tlaskal V, Galanova N, et al. Oral microbiota composition and antimicrobial antibody response in patients with recurrent aphthous stomatitis. Microorganisms. 2019; 7(12):636.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 . Tannishtha, S. Hegde, G. S. Babu, V. Ajila, B. S. Shama (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
You are free to share, copy and redistribute the material in any medium or format under these terms.
Journal Acta Medica Bulgarica 
