Behavioral effects of chronic Japanese quince fruit juice administration to rats with diet-induced metabolic syndrome
DOI:
https://doi.org/10.2478/AMB-2024-0017Keywords:
anxiety, Chaenomeles japonica, depression, medicinal plantsAbstract
Introduction: Metabolic syndrome (MS) is often associated with anxiety and depression. Chaenomeles japonica (Thunb.) Lindl, also known as Chaenomeles maulei or Japanese quince, is a medicinal plant with a long history of use for its health-promoting properties. Aim: The aim of this study was to investigate the effects of Japanese quince fruit juice (JQFJ) administration on locomotor activity, anxiety and depressive behavior in rats with diet-induced MS. Materials and methods: Forty adult male Wistar rats were divided into 4 groups: MS, MS+JQFJ2.5, MS+JQFJ5 and MS+JQFJ10. All groups received a high-fat high-fructose diet for the induction of MS. MS animals were daily orally treated with distilled water and the other groups with JQFJ at doses of 2.5 ml/kg, 5 ml/kg and 10 ml/kg, respectively. During the 10th week of the experiment, behavioral tests were carried out. Results: In the open field test, no effect of JQFJ treatment on locomotor activity was observed. In the elevated plus maze test, a dose-dependent increase in the time spent in the open arms (OA) of the apparatus and in the ratio time spent in OA vs. total time spent in any of the arms was interpreted as an anxiolytic effect. The immobility time in the forced swim test did not differ significantly among the groups, which demonstrated a lack of antidepressant action. Conclusions: Chronic Japanese quince fruit juice administration produced a dose-dependent anxiolytic-like effect in rats with diet-induced MS, probably due to its high content of polyphenols.
References
Sartori SB, Singewald N. Novel pharmacological targets in drug development for the treatment of anxiety and anxietyrelated disorders. Pharmacol. Ther. 2019; 204: 107402.
Ji S, Chen Y, Zhou Y et al. Association between anxiety and metabolic syndrome: An updated systematic review and meta-analysis. Front. Psychiatry 2023; 14: 1118836.
Weber C. The genus Chaenomeles (Rosaceae). J. Arnold Arbor. 1964; 45(3): 302-345.
Borisova V, Eftimov M, Valcheva-Kuzmanova S. Anxiolyticlike effects of Chaenomeles maulei fruit juice in an elevated plus maze test. Collection of articles from the National Scientific Conference “15 Years of Pharmacy in Medical Univeristy – Plovdiv” 2018: 93-99.
Borisova-Nenova V, Eftimov M, Valcheva-Kuzmanova S. Behavioral effects of Chaenomeles maulei fruit juice in rats with impaired circadian rhythm. Folia Medica 2023; 65(1): 155-160.
Valcheva-Kuzmanova S, Denev P, Ognyanov M. Chemical composition and antioxidant activity of Chaenomeles maulei fruit juice. J. Biomed. Clin. Res. 2018; 11(1): 41-48.
Gancheva S, Galunska B, Zhelyazkova-Savova M. Diets rich in saturated fat and fructose induce anxiety and depression-like behaviours in the rat: is there a role for lipid peroxidation? Int. J. Exp. Pathol. 2017; 98(5): 296-306.
Borisova V, Eftimov M, Valcheva-Kuzmanova S. Behavioral effects of the subchronic Chaenomeles maulei fruit juice administration to healthy male rats. Bulg. Chem. Comm. 2019; 51(A): 18-21.
Kumar A, Pramanik J, Goyal N et al. Gut microbiota in anxiety and depression: unveiling the relationship and management options. Pharmaceuticals 2023; 16(4): 565.
Aloo S-O, Ofosu FK, Kim N-H et al. Insights on Dietary Polyphenols as Agents against Metabolic Disorders: Obesity as a Target Disease. Antioxidants. 2023; 12(2):416.
Dias GP, Cavegn N, Nix A et al. The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety. Oxid Med Cell Longev. 2012; 541971. doi:10.1155/2012/541971.
Tchantchou F, Lacor PN, Cao Z et al. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis. 2009; 18(4): 787-98.
Pitsavos C, Panagiotakos DB, Papageorgiou C et al. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study. Atherosclerosis 2006; 185(2): 320-326.
Vogelzangs N, Beekman ATF, de Jonge P et al. Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry 2013; b3(4): e249.
Yahfoufi N, Alsadi N, Jambi M et al. The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients. 2018; 10(11): 1618.
Vestegani SM, Hajipour S, Sarkaki A et al. Vanillic acid alleviates lipopolysaccharide-induced anxiety/depression-like behaviors and cerebral oxidative stress in male rats. Learn. Motiv. 2022: 78.
Monteiro ÁB, Kelly de Souza Rodrigues C, Petícia do Nascimento E et al. Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice. Food Chem Toxicol. 2020; 136: 111049.
Chen XD, Tang JJ, Feng S et al. Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms. Curr Neuropharmacol. 2021; 19(12): 2180-2187.
Scheepens A, Bisson JF, Skinner M. p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo. Phytother Res. 2014; 28(2): 207-211.
Islam MS, Hossain R, Ahmed T et al. Anxiolytic-like effect of quercetin possibly through GABA receptor interaction pathway: in vivo and in silico studies. Molecules 2022; 27: 7149.
Silva Dos Santos J, Gonçalves Cirino JP, de Oliveira Carvalho P et al. The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review. Front Pharmacol. 2021; 11: 565700.
Kang J, Oteiza PI, Milenkovic D. (-)-Epicatechin exerts positive effects on anxiety in high fat diet-induced obese mice through multi-genomic modifications in the hippocampus. Food Funct. 2022; 13(20): 10623-10641.
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Copyright (c) 2024 K. Moneva-Marinova, E. Rafailova, M. Reyzov, M. Todorova, M. Eftimov, S. Gancheva, M. Zhelyazkova-Savova, S. Valcheva-Kuzmanova (Author)
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Journal Acta Medica Bulgarica 
