Диагностична и прогностична стойност на възпалителните и нутритивно-имунните индекси при овариален карцином
Ключови думи :
овариален карцином, възпалителни индекси, NLR, PLR, SII, PNI, FIGO стадий, прогноза, ROC анализАбстракт
Овариалният карцином е сред най-смъртоносните гинекологични злокачествени заболявания най-вече поради късната диагностика. Нараства интересът към възпалителните (NLR, PLR и SII) и нутритивно-имунните (PNI) индекси като достъпни и евтини биомаркери с потенциална диагностична и прогностична стойност. В настоящото проучване установихме статистически значима зависимост между стойностите на всички изследвани индекси и стадия на заболяването. С напредване на FIGO стадия се наблюдава повишаване на NLR, PLR и SII и понижаване на PNI (p < 0,05). Всички индекси показаха добра диагностична способност за разграничаване на ранен и напреднал стадий. Най-висока AUC установихме при PNI (AUC = 0,899). Оптималните cut-off стойности, които определихме в нашето изследване, са: NLR ≥ 3,17; PLR ≥ 214; SII ≥ 1132,9; PNI ≤ 33,9. Определяните от нас индекси са достъпни и информативни биомаркери с добра диагностична и прогностична стойност при овариален карцином. Те могат да се използват за индивидуализиране на терапевтичния подход и за ранното стратифициране на риска. Необходими са бъдещи мултицентрови проучвания за уеднаквяване на cut-off стойностите и утвърждаване на клиничното им приложение.
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Списание Bulgarian Medical Journal (Български медицински журнал / Bulgarian Medical Journal) ISSN: 1313-1516 (Print)
