Operative tratment of locally advanced breast cancer
Keywords:
axillary lymph dissection, drug therapy, locally advanced breast cancer, modified radical mastectomy, radical mastectomy, radiotherapyAbstract
The purpose of the present report is to submit our experience with the operative treatment of 56 female patients at a mean age of 62.32 ± 14.57 years with locally advanced breast cancer during the period between September 9, 2018 and March 27, 2024, in the city of Varna. The disease is right-sided in 32 women, left-sided in 23 women, and bilateral in one woman. A total of ten types of operative interventions were used. Radical mastectomy (in 14), quadrantectomy (in 13), Auchincloss’ mode modified radical mastectomy (in 9), and simple mastectomy (in 6) prevail. The sectoral resection, Pirogov’s mode modified radical mastectomy and Scanlon’s mode modified radical mastectomy are performed in 3 patients each. The axillary lymph dissection is used in 35 patients. The postoperative period was uneventful. The individualized surgical treatment of the patients with locally advanced breast cancer within the multimodal approach is sufficiently effective and safe.
References
Luțenco V, Rebegea L, Beznea A, et al. Innovative surgical approaches that improve individual outcomes in advanced breast cancer. Int J Womens Health, 2024,16:555-560.
Maes-Carballo M, Martín-Díaz M, García-García M, et al. Decision aids for decision making about locally advance breast cancer: a systematic review. Cancer Invest, 2023, 12:1-13.
Conti M, Morciano F, Bufi E, et al. Surgical planning after neoadjuvant treatment in breast cancer: a multimodality imaging-based approach focused on MRI. Cancers (Basel), 2023, 15:1439.
Lorenzo R, Meani F, Longhitano C, et al. The optimal timing between neoadjuvant therapy and surgery of breast cancer: a brief systematic review of the literature. Crit Rev Oncol Hematol, 2023, 183:103921.
Malhotra S, Tadros AB. New strategies for locally advanced breast cancer: a review of inflammatory breast cancer and nonresponders. Clin Breast Cancer, 2024, 24(4):301-309.
Kolářová I, Melichar B, Sirák I, et al. The role of adjuvant radiotherapy in the treatment of breast cancer. Curr Oncol, 2024, 31:1207-1220.
da Costa Vieira RA, Ching AW, de Oliveira-Junior I. Breast reconstruction for locally advanced breast cancer previously submitted to mastectomy and an ipsilateral thoracoabdominal dermofat (ITADE) flap. Breast Dis, 2023, 42:229-232.
Marian D, Fulop ZZ, Fulop RL, et al. Locally advanced breast cancer in Eastern European developing countries. Ann Ital Chir, 2023, 94:346-350.
Whalen K, Liu L, Rejano CJ, et al. Reverse abdominoplasty for mastectomy defect closure in advanced breast cancer. Ann Plast Surg, 2023, 90:204-208.
Ali OAH, Elhaj A. How can oncoplastic breast surgery contribute to the management of locally advanced breast cancer in Sub-Saharan Africa? Breast Care (Basel), 2023, 18:336-343.
Wijesinghe K, Abeywickrama T, Chamara Y, et al. Oncoplastic breast conserving surgery versus standard breastconserving surgery for early and locally advanced breast cancer: a retrospective analysis from Sri Lanka. BMC Surg, 2023, 23:273.
Nobrega GB, Mota BS, de Freitas GB, et al. Locally advanced breast cancer: breast-conserving surgery and other factors linked to overall survival after neoadjuvant treatment. Front Oncol, 2023, 13:1293288.
Sondezi MN, Buccimazza I, Madlala NB. Outcomes of breast conserving therapy: recurrence, imaging findings and histological correlation. SA J Radiol, 2023, 27:2592.
Retamales J, Daneri-Navarro A, Artagaveytia N, et al.; Latin American Cancer Research Network (LACRN). Implementing standard diagnosis and treatment for locally advanced breast cancer through global research in Latin America: results from a multicountry pragmatic trial. JCO Glob Oncol, 2024, 10:e2300216.
Dave S, Choudhury A, Alurkar SS, et al. Is Ki-67 really useful as a predictor for response to neoadjuvant chemotherapy in locally advanced breast cancer? Indian J Surg Oncol, 2024, 15:44-52.
Terasawa T, Sakurai Y, Yanai A, et al. A case of pathological complete response following neoadjuvant S-1 monotherapy in an elderly patient with locally advanced breast cancer. Gan To Kagaku Ryoho, 2023, 50:1339-1341 (in Japanese).
Brahma B, Yamamoto T, Agdelina C, et al. Immediate-delayed lymphatic reconstruction after axillary lymph nodes dissection for locally advanced breast cancer-related lymphedema prevention: Report of two cases. Microsurgery, 2024, 44(2):e31033.
Iyer P, Krishnamurthy A, Velusamy S, et al. Effect of neoadjuvant concurrent chemoradiation on operability and survival in locally advanced inoperable breast cancer. Int J Radiat Oncol Biol Phys, 2024, 119:163-171.
Lin YH, Chidley P, Admojo L, et al. Pathologic complete response and oncologic outcomes in locally advanced breast cancers treated with neoadjuvant radiation therapy: an Australian perspective. Pract Radiat Oncol, 2023, 13:301-313.
Wang X, Meng J, Zhang X, et al. The role of radiotherapy for patients with unresectable locally advanced breast cancer following neoadjuvant systemic therapy. J Oncol, 2023, 2023:5101078.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
You are free to share, copy and redistribute the material in any medium or format under these terms.

Journal Bulgarian Medical Journal (Български медицински журнал / Bulgarian Medical Journal)