High colchicine doses are really silver bullets against COVID-19
DOI:
https://doi.org/10.2478/AMB-2024-0085Keywords:
COVID-19, colchicine, NLRP3 inflammasome, cytokine storm, colchicine toxicityAbstract
The numerous attempts to prove a therapeutic effect of low-dose colchicine for the treatment of Coronavirus disease-2019 (COVID-19) have been discouraging. Increase of doses, however, leads to accumulation in leukocytes and inhibition of the cytokine storm thus preventing COVID-19 complications and hospitalizations. Hospital mortality drops up to 7 fold, while outpatients practically do not reach hospitalization.
References
Mitev V. Comparison of treatment of Covid-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovide, mornupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib. Pharmacia. 2023;70: 1177-93.
Rabbani AB, Oshaughnessy M, Tabrizi R, Rafique A, Parikh RV, Ardehali R. Colchicine and COVID-19: A Look Backward and a Look Ahead. Medical Research Archives. 2024, 12 (9) doi.org/10.18103/mra.v12i10.5835
Mitev V. Colchicine—The Divine Medicine against COVID-19. J Pers Med. 2024;14:756.
RECOVERY Collaborative Group. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet (London, England). 2023;401(10387):1499.
Terkeltaub RA, Furst DE, Bennett K, Kook KA, Crockett RS, Davis MW. High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis Rheum. 2010;62:1060–8.
Leung YY, Yao Hui LL, Kraus VB. Colchicine-Update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum. 2015;45:341-50.
Melms JC, Biermann J, Huang H, et al. A molecular single-cell lung atlas of lethal COVID-19. Nature. 2021;595:114–9.
Tiholov R, Lilov AI, Georgieva G, Palaveev KR, Tashkov K, Mitev V. Effect of increasing doses of colchicine on thetreatment of 333 COVID‐19 inpatients. Immun Inflamm Dis. 2024;12:e1273.
Mondeshki T, Bilyukov R, Mitev V. Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion. Cureus. 2023; 15(3):e35909
Mitev V. What is the lowest lethal dose of colchicine? Biotechnol Biotechnol Equip. 2023;37:1.
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Journal Acta Medica Bulgarica 
