Darier’s disease: a case report and review of literature
DOI:
https://doi.org/10.2478/AMB-2026-0013Keywords:
Darier’s disease, clinical features, diagnosis, treatmentAbstract
Abstract. Introduction: Darier’s disease is an autosomal dominant disorder caused by mutations in the ATP2A2 gene, and clinically presented with hyperkeratotic papules and plaques in a seborrheic region. Clinical Case Description: We observed a 48-year-old male patient who presented with persistent pruritic skin lesions on the trunk and extremities. Physical examination revealed erythematous and hyperkeratotic papules and follicular keratosis. The diagnosis of Darier’s disease was based on the clinical presentation and confirmed with histological examination. Treatment with low-dose methylprednisolone resulted in significant improvement. Discussion and Conclusions: The case highlights the importance of considering Darier’s disease in patients with persistent pruritic skin lesions and emphasizes the need for accurate diagnosis and adequate treatment.
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Journal Acta Medica Bulgarica 
